CTLA4 and colitis: In line with this, colonic mRNA expression of IL-17A was shown to be upregulated in nine anti-CTLA-4-induced colitis patients compared to eight healthy controls as well as interferon-γ, FoxP3, IL-10 and TNF-like molecule TL1A in a study of mRNA expression of 14 inflammatory mediators in colon tissue biopsies (68).