Interestingly, we found that both SH3KBP1 mRNA and protein expression levels were dramatically increased in tumor spheres derived from U251, U87, and LN229 cells than their corresponding monolayer cells (Figures 2C–E), suggesting that SH3KBP1 plays critical roles in regulating GSCs self-renewal. The gene discussed is SH3KBP1; the disease is neoplasm.