CD4 and cranioectodermal dysplasia: The T‐cell autocrine cytokine IL‐2 is secreted by gluten specific CD4+ T cells upon intake of gluten and is now considered the major driver of immediate gastrointestinal symptoms to gluten in CeD patients.[13] Also in patients from the current study, mean fold increase in plasma IL‐2 within <6 h after gluten intake correlated with baseline frequency of gluten‐specific CD4+ T cells in blood.[13] Thus, development of symptoms and mucosal pathology in response to gluten is linked to the magnitude of antigluten immunity present at the time of gluten consumption.