The T‐cell autocrine cytokine IL‐2 is secreted by gluten specific CD4+ T cells upon intake of gluten and is now considered the major driver of immediate gastrointestinal symptoms to gluten in CeD patients.[13] Also in patients from the current study, mean fold increase in plasma IL‐2 within <6 h after gluten intake correlated with baseline frequency of gluten‐specific CD4+ T cells in blood.[13] Thus, development of symptoms and mucosal pathology in response to gluten is linked to the magnitude of antigluten immunity present at the time of gluten consumption. This evidence concerns the gene IL2 and cranioectodermal dysplasia.