GSTM1 and neoplasm: Herein, we developed a facile X‐ray nanoprocessor (Hb@Hf‐Ce6 NPs) based on metal‐phenolic coordination for oxygen delivery and X‐ray‐triggered ultrasensitive ROS generation in tumor region to overcome immunosuppressive TME and achieve enhanced tumor inhibition by combination of RT‐RDT integrated with checkpoint blockade immunotherapy (Figure 1).