Oxygen‐enriched X‐ray nanoprocessor Hb@Hf‐Ce6 nanoparticles are developed for improving therapeutic effect of radiotherapy‐radiodynamic therapy, enhancing modulation of hypoxia tumor microenvironment, and promoting antitumor immune response in combination with anti‐PD‐1 antibody. This evidence concerns the gene PDCD1 and neoplasm.