GBM angiogenesis microchip model, integrating macrophages, endothelial cells and an ECM‐mimetic hydrogel. The constructs polarized macrophages toward an M2‐like phenotype, which promoted angiogenesis and immunosuppression. A key role of TGF‐β1 and surface integrin (α5β3) was required for establishing this immunosuppressive environment. This evidence concerns the gene TGFB1 and glioblastoma.