TBX1 and cancer: Human mammary fibroblasts (HMFs) and MDA‐MB‐231 mamospheres were cultured in such hydrogels, which stimulated fibroblasts to remodel the collagen microstructure, facilitating cancer cells invasion.[176] Col I/alginate hydrogel platforms were also explored to evaluate ECM remodeling influence in the cross‐talk between CAFs and cancer cells.