FN1 and neoplasm: By using this elegant set up, it was observed that the combination of both anticancer drugs elicited a reduction of tumor growth and invasion, as well as a reduction in the overall stiffness induced by a decrease in the collagen density and fibronectin disruption.[167] These findings further evidence the importance of recapitulating the tumor stroma to learn about the action mechanisms of new therapeutics, as the results outcome is influenced by the proper recapitulation of the TME.