Hydrogels for in vitro tumor modeling can be engineered from a wide range of natural biomaterials, such as polysaccharides (e.g., alginate, hyaluronic acid (HA), etc.), proteins (e.g., collagen, gelatin, fibronectin, laminin, fibroin, etc.), from synthetic materials including (PEG, self‐assembled peptides, etc.), or tissues/organs derived decellularized ECM (dECM, e.g., Matrigel, Geltrex, Cultrex, etc.). Here, FN1 is linked to neoplasm.