HA can specifically recognize overexpressed CD44 on the surface of pancreatic tumor cells for facilitating the internalization of supramolecular nanoparticles.[28, 29] Once internalized into tumor cells, PPa is able to generate ROS under near‐infrared (NIR) laser irradiation, which promotes activation and intratumoral infiltration of CD8+ T lymphocytes. This evidence concerns the gene CD44 and pancreatic neoplasm.