CDKN2A and colorectal carcinoma: To further validate the direct association between the presence of senescent tumor cells and the suppression of antitumor T cell immunity in CRC, we generated an AOM/DSS‐induced CRC mouse model that faithfully mimics human CRC.[33] All the tumors contained SA‐β‐Gal and p16INK4A positive senescent tumor cells (Figure 7A,B).