We further confirmed cellular senescence using another senescent marker, histone H3K9me3 (H3K9 trimethyl) (Figure S1C, Supporting Information).[21] Moreover, p16INK4A positive cells were positive for CDX2 immunostaining but negative for vimentin, indicating that these cells were not stromal cells but rather cancer epithelial cells (Figure S1D,E, Supporting Information). This evidence concerns the gene VIM and cancer.