Finally, we investigated CXCR4 protein expression in CD8+ T cells in vivo, and we found that its expression on CD8+ T cells was maintained in the infiltrated intratumoral region of p16INK4A negative CRC, but it decreased or was absent in p16INK4A positive CRC (Figure 4I). This evidence concerns the gene CXCR4 and colorectal carcinoma.