The expression of CXCL9, CXCL10, CXCL11, CXCL12, and CXCL16 were further analyzed by immunohistochemical staining; the results showed that CXCL9, CXCL10, CXCL11, and CXCL16 were not or expressed weakly in CRC cells and were only occasionally expressed in stromal cells (Figure S3A, Supporting Information), but CXCL12 was expressed in the areas where p16INK4A positive tumor cells were found. This evidence concerns the gene CXCL12 and neoplasm.