CD8A and colorectal carcinoma: To determine whether the infiltrated CD8+ T cells were activated or exhausted, we performed CD8/Ki67 co‐immunostaining and found an increased number of activated CD8+ T cells in the intraepithelial of p16INK4A negative CRC when compared to those cells in p16INK4A positive CRC stromal (26.1% vs 9.9%).