The immune cell infiltration in CRC is possibly associated with MSI‐related high mutational loads.[22] In addition, mucinous carcinoma has been found to be associated with the presence of MSI and immune cell infiltration.[23] To exclude the association of immune cell infiltration by MSI positive CRC or mucinous CRC and to elucidate the role of p16INK4A positive senescent tumor cells in immune infiltration, we excluded ten cases of MSI positive and mucinous cancers. This evidence concerns the gene CDKN2A and colorectal carcinoma.