The inducing effect of CM‐HCC/RNF219 on osteoclastogenesis and activation of integrin αv/β3‐signalling, evidenced by the increased phosphorylation level of SRC, SYK, and VAV‐3 and expression of RAC‐GTP, was profoundly mitigated by CD98‐ or integrin β3‐silencing (Figure 2I and Figure S3I, Supporting Information). This evidence concerns the gene VAV3 and hepatocellular carcinoma.