OBI1 and hepatocellular carcinoma: The inducing effect of CM‐HCC/RNF219 on osteoclastogenesis and activation of integrin αv/β3‐signalling, evidenced by the increased phosphorylation level of SRC, SYK, and VAV‐3 and expression of RAC‐GTP, was profoundly mitigated by CD98‐ or integrin β3‐silencing (Figure 2I and Figure S3I, Supporting Information).