OBI1 and hepatocellular carcinoma: Although the mRNA level of RNF219 was also significantly increased in HCCLM3‐BM4 cells compared to HCCLM3‐P cells (Figure S8A, Supporting Information), genomic DNA and TCGA dataset analyses showed that the genomic locus of RNF219 was not amplified in bone‐metastatic HCC cells and tissues, which indicated that RNF219 upregulation was not associated with genomic gain.