Analysis of the protein profiling in CM collected from HCC/vector and HCC/RNF219 cells and the proteomics data of mature osteoclast (OC) and osteoclast precursor (OP), [15] indicated that LGALS3 was one of the secreted proteins with the most pronounced upregulation in HCC/RNF219 cells and OCs (Figure 2B and Table S7, Supporting Information). This evidence concerns the gene LGALS3 and hepatocellular carcinoma.