Among them, ubiquitin ligase RNF219 was found consistently elevated in high‐bone‐metastatic HCC cells and tissues compared to low‐bone‐metastatic HCC cells, non‐metastatic or other organ metastatic HCC tissues, respectively (Figure S1A,B, Supporting Information and Figure 1B,C). Here, OBI1 is linked to hepatocellular carcinoma.