Interestingly, we did not observe that HCC‐secreted LGALS3 interacted with osteoclast differentiation inhibitor myosin‐2A.[17] However, we found that LGALS3 bound to and stabilized CD98 and integrin αv/β3, the key factors in osteoclastogenesis and osteoclast activation,[18] in osteoclasts surface (Figure 2E,H and Figure S3H, Supporting Information). This evidence concerns the gene LGALS3 and hepatocellular carcinoma.