Our CAPTURE/MS analyses revealed that DNA methyltransferase DNMT1, methylcytosine dioxygenase TET1, CHTOP/arginine methyltransferase PRMT1‐methylosome complex, and histone methyltransferase complex MLL4/WDR5 were also enriched at LGALS3 promoter in RNF219‐upregulated HCC cells (Figure 4A). This evidence concerns the gene PRDM9 and hepatocellular carcinoma.