Therefore, these results further support our hypothesis that RNF219‐mediated α‐catenin degradation prompted LGALS3 upregulation via YAP1/β‐catenin‐dependent epigenetic modifications, which results in metastatic bone diseases, and verteporfin treatment might be a new therapeutic approach against HCC‐BM (Figure 8D). This evidence concerns the gene OBI1 and hepatocellular carcinoma.