LGALS3 and Familial prostate cancer: Indeed, breast cancer‐secreted LGALS3 nullified the suppressive effect of myosin‐2A on osteoclast differentiation and prostate cancer‐secreted cleaved LGALS3 activated Notch signaling to induce osteoblast differentiation.[17] We demonstrated that HCC‐secreted LGALS3 localized on the outer membrane surface of osteoclast progenitor cells and formed lattices with and activated CD98‐ and integrin αv/β3 complex–mediated fusion and podosome formation of osteoclasts, leading to osteolytic bone remodeling.