However, the osteoclastogenic effect of α‐catenin silencing on HCC cells‐mediated osteoclastogenesis was abrogated by LGALS3 ablation (Figure 5A and Figure S4D, Supporting Information), strongly indicating a critical role of RNF219/α‐catenin/LGALS3 axis in the regulation of osteoclastogenesis in vivo. The gene discussed is OBI1; the disease is hepatocellular carcinoma.