Consistent with the biological function of each trans‐regulatory complex, the relative 5hmc/5mc ratio and levels of H4R3me2a and H3K4me3 on LGALS3 promoter were increased in RNF219‐upregulated and α‐catenin‐silenced HCC cells but decreased in RNF219‐silenced and α‐catenin‐transduced cells (Figure 6F,G). This evidence concerns the gene LGALS3 and hepatocellular carcinoma.