We further found that accompanied by severe erosion in the bone slice by Raw 264.7 cells, treated with CM‐HCC/RNF219 (Figure 3A), the bone matrix‐released TGF‐β was also significantly elevated that further promoted the proliferation of HCCLM3‐BM4 cells (Figure S9C, Supporting Information). Here, OBI1 is linked to hepatocellular carcinoma.