DNMT1 and colorectal cancer: Although DNA methylation is a major epigenetic mechanism for gene silencing,[21] binding of DNMT1 has been reported to increase nuclear β‐catenin level and induced β‐catenin/TCF‐driven transcription and DNA methylation in colorectal cancer cells.[22] DNMT1‐mediated C5 position of cytosine bases (5mC) in CpG dinucleotide might also play an important role in transcriptional regulation.