A number of chromosomal translocations such as t(8;21)(q22;q22) or t(15;17)(q22;q21), insertions, deletions, and inversions, have been previously reported in AML, along with a wide range of molecular alterations in various genes such as TET2, FLT3, NPM1, CEBPA, DNMT3 have been described, which have a prognostic significance in such patients (Weissmann et al., 2012). Here, NPM1 is linked to acute myeloid leukemia.