In Ley et al. (2008), were the first to performed whole genomic sequencing study on a Caucasian woman diagnosed with AML-M1 (cytogenetically normal), and reported non-synonymous single nucleotide variants (nsSNVs) in eight genes (i.e., CDH24, PCLKC, GPR123, EBI2, PTPRT, KNDC1, SLC15A1, and GRINL1B) and insertions in the coding regions of the FLT3 and NPM1 genes. Here, FLT3 is linked to acute myeloid leukemia.