NPM1 and acute myeloid leukemia: In Ley et al. (2008), were the first to performed whole genomic sequencing study on a Caucasian woman diagnosed with AML-M1 (cytogenetically normal), and reported non-synonymous single nucleotide variants (nsSNVs) in eight genes (i.e., CDH24, PCLKC, GPR123, EBI2, PTPRT, KNDC1, SLC15A1, and GRINL1B) and insertions in the coding regions of the FLT3 and NPM1 genes.