A study on human glioblastoma multiforme T98G cells also evaluated the effect of quercetin that is an anti-oxidant, and temozolomide, which is used to treat brain tumors, singly and in combination on the induction of apoptosis and autophagy, and findings showed that the combination of these two drugs significantly increased caspase-3 and 9 activity (26). Here, CASP3 is linked to brain neoplasm.