Of the 12 lipid species significantly up‐regulated in apical sEV derived from inflammatory versus normal PTEC, four ceramide species (Cer d18:1/16:0, Cer d18:1/20:0, Cer d18:1/22:0, Cer d18:1/24:0) have been previously reported as elevated in the urine of diabetic nephropathy patients and correlating with urinary biomarkers of renal tubular injury (e.g., N‐acetyl‐β‐D‐glucosaminidase; NAG) (Morita et al., 2020). This evidence concerns the gene CBLN1 and diabetic kidney disease.