For example, β-adrenergic agonists improve cardiac contractility, but also increase mortality in HF, while neurohormonal inhibition, a meaningful intervention for HF, is restricted by its side effect, such as deterioration of renal function, potassium retention, and angioedema caused by angiotensin-converting enzyme inhibitor (ACEI) [4, 5]. This evidence concerns the gene ACE and hydrops fetalis.