It is reported that an important type of receptor NLRP3 inflammatory signal axis exists in innate immunity, named, NLRP3-ASC-caspase-1 signal axis (NLRP3 signal axis) [22, 23], which can mediate NAFLD-induced inflammation and oxidative stress response [24, 25]. The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.