Immune deficiency in natural killer cells (Witalisz et al., 2019), the mutation of JAK1 was related to immune escape in many cancers (Xie et al., 2009; Albacker et al., 2017) apoptosis and growth in several cancers (Siavash et al., 2004) optimal fitness of activated B cell (Zhu et al., 2017). The gene discussed is JAK1; the disease is Immunodeficiency.