However, given the lack of phenotype in the Slc22a4tm1.1(KOMP)Vlcg and the presence of the variant at the homozygous state in one normal-hearing individual, we cannot completely exclude the following: (1) SLC22A4 is the causative gene but the rs768484124 is not the deafness-associated variant or (2) SLC22A4 is not the causative gene and does not contribute to hearing function. The gene discussed is SLC22A4; the disease is deafness.