After the analysis with CIBER-SORT, inferred immune cell compositions in the RA and HC groups were visualized (Figure 9A); the corresponding volcano plot (Figure 9B) showed that the percentages of five immune cells including macrophages M1, gamma delta T cells, CD8(+) T cells, plasma cells, and memory B cells were significantly elevated in the RA group (red horizontal dash line on the y axis indicates a q-value of 0.05). This evidence concerns the gene CD8A and rheumatoid arthritis.