Based on our current data and previous studies, we hypothesize that KrasG12D, PI3K, ERK, JNK, p38MAPK, vimentin, lncRNA MALAT1, lncRNA SNHG1, and lncRNA RP11-363N22.3 targeted by hsa-miR-143-3p may play crucial roles in pancreatic cancer. This evidence concerns the gene MALAT1 and pancreatic neoplasm.