Compared with the NCs exosomes, the active SLE exosomes induced CD4+ T cells to produce significantly higher levels of IFN-γ, TNF-α, and IL-6, according to the results of RT-qPCR (Figures 1C–E) and flow cytometry (Figures 2A,B). The gene discussed is CD4; the disease is systemic lupus erythematosus.