IL6 and systemic lupus erythematosus: MIF can further co-stimulate T and B cells, up-regulate the secretion of INF-γ, IL-6, TNF-α, etc. to form a positive feedback loop, maintain pro-inflammatory activity and inhibit the activation of apoptotic signaling pathways to be involved in the occurrence and development of SLE which may be our next research direction (55, 56).