The Myb-like, SWIRM, and MPN domains 1 protein (MYSM1, a metalloprotease, which deubiquitinates the K119-monoubiquitinated form of the H2A) is another cGAS-STING negative regulator that upregulates after viral infection and intracellular DNA stimulation (116, 117). This evidence concerns the gene MYSM1 and viral infectious disease.