AIM2 and malignant colon neoplasm: AIM2-/- mice are more susceptible to develop colon cancer following azoxymethane (AOM)-and dextran sulfate sodium (DSS)-induced colitis-associated carcinogenesis due to the uncontrolled proliferation of intestinal stem cells (ISCs) in response to the aberrant activation of Wnt (Wingless and Int-1) signaling and dysbiosis of the gut bacteria (306).