AIM2 and cancer: AIM2 also regulates growth and invasion of squamous cell carcinoma (SCC) of the skin or keratinocyte-derived cutaneous squamous cell carcinoma (c-SCC) through increasing the cancer cell viability and invasion as indicated by the increased production of matrix metalloprotease 13 (MMP13) and MMP1 (two proteases with collagen degrading and invasion promoting properties associated with the invasion of c-SCC cells) and vascularization (311).