The cGAS-STING signaling induced through the self-dsDNA plays a crucial role in various sterile inflammatory diseases, including ataxia-telangiectasia (AT, its patients are more prone to develop cancer), non-alcoholic steatohepatitis (NASH) or fatty liver disease (NAFLD) via recognizing mtDNA as a potential DAMP in Kupffer cells of the liver), the chronic exposure of STING activator (5,6-dimethylxanthenone-4-acetic acid or DMXXA) also induces NASH or NAFLD in WT mice (20, 119, 120). The gene discussed is STING1; the disease is metabolic dysfunction-associated steatohepatitis.