The wild type (WT) mice subjected to the cecal-ligation and puncture (CLP)-induced sepsis show increased systemic inflammation, gut permeability, translocation of the bacteria due to the death of enterocytes in response to the recognition of the cytosolic mtDNA as STING-/- mice have alleviated inflammatory immune response and decreased bacterial translocation (108). The gene discussed is STING1; the disease is Sepsis.