Also, the mtDNA damage in endothelial cells during a high-fat diet containing palmitic acid (PA) activates cGAS-STING signaling that activates IRF3, which induces intercellular adhesion molecule-1 (ICAM-1) expression inducing monocyte endothelial cell interaction/adhesion causing adipose tissue inflammation, obesity, inflammation, glucose intolerance, and insulin resistance (125). The gene discussed is ICAM1; the disease is obesity due to melanocortin 4 receptor deficiency.