Among those, there was not a clear association between Bla g 2-specific IgE levels and severity of the disease: whereas three out of those six with the highest levels of IgE to Bla g 2 (63.6, 6.1 and 5.36 kUA/L) had allergic rhinitis and moderate to severe asthma, among the three subjects with the lowest IgE levels (2.25 to 2.79 kUA/L), two had mild asthma and one moderate to severe asthma. This evidence concerns the gene IGHE and allergic rhinitis.