Of note, reducing IL-6 in the TME may not only help abrogate the symptoms of CRS, but it has the potential to simultaneously limit the effect of TAMs, since TME-derived IL-6 is often implicated in the pathogenesis of many cancers due to its positive feedback loops that promote tumor growth, such as in ovarian cancer, breast cancer, and multiple myeloma (107–110). Here, IL6 is linked to AL amyloidosis.