Tauriello and colleagues reported a set of GEMMs with mutations in one or more of the CRC-associated genes Apc, Kras, Tgfbr2, and Trp53 (87); these models recreate many features of the human TME, including well-differentiated cancer cells, desmoplasia, and metastasis to the lung and liver. This evidence concerns the gene APC and colorectal carcinoma.