It is well known that many cell types, including mast cells, respond to viral infections through TLR3, TLR7, and TLR9 initiating the type I IFN response as well as release of various proinflammatory cytokines (7, 8), which make them targets for antiinflammatory treatments including the use of cytokines of the IL-1 family with antiinflammatory properties (39, 40). This evidence concerns the gene IL1B and viral infectious disease.