Considering that our data showed the same pattern of immunostaining in the SSc-ILD lung biopsies, incubated with anti-ColV IgG without previous absorption and after absorption with α2(V) chain (anti-ColV IgG/ads-α2(V)), we evaluated a possible correlation, between SSc-ILD lung biopsies immunostaining with anti-Col V peptides (Table 1) detected in early-SSc sera, who tested positive to anti-Col V. Interestingly, we found a strong and significant correlation to anti-Pept Col5A1(599) (r=0.930; p=0.007) and Anti-Pept Col5A1(779) (r=0.854; p=0.030) (Supplementary Table 3). This evidence concerns the gene COL5A1 and interstitial lung disease.