Bearing in mind that IL-17 is involved in certain severe cases of asthma likely by regulating neutrophilic inflammation (10) together with our present observation that Vγ1+ γδ and CD4+ T cells from the lung of NOD HDM mice produced high levels of this cytokine (Figure 2), and that NOD IL-4KO HDM mice presented higher levels of neutrophils in the airway (Figures 3A, B), we further examined whether IL-17 contributed to the airway inflammation and AHR observed in NOD IL-4KO HDM mice. The gene discussed is IL17A; the disease is asthma.