MetS was higher in PsA patients compared with the control group: 54.8% versus 36.6%, respectively (P = 0.02). Leptin levels and leptin/adiponectin ratio were higher in PsA patients compared with controls: 83.4 versus 51.7 ng/mL (P = 0.001) and 6.3 × 10−3 versus 4.1 × 10−3 (P = 0.015), respectively. This evidence concerns the gene LEP and metabolic syndrome.