The frequencies of TA haplotypes (composed by rs17549193 and rs7851696 encoding the ancestral amino acids threonine at position 236 and alanine at position 258 of the ficolin-2 protein, respectively) were higher among HBV+ than among HBV− leprosy patients (OR = 2.19 [95%CI = 1.14–4.23], P = 0.022). The gene discussed is FCN2; the disease is leprosy.