Haplotypes with the AAAGDelT combination are associated with higher FCN1 gene expression and were associated with protection against HBV infection, particularly FCN1*3C2. On the other hand, the FCN1*3A.3C2.B haplotype and the more ancient FCN*1 haplotype were associated with lower FCN1 gene expression and higher susceptibility to HBV and leprosy/HBV infection, respectively. The gene discussed is FCN1; the disease is leprosy.