Chondroitin sulfate proteoglycan 4 (CSPG4, also known as neuron-glial antigen-2, NG2) is a type of single transmembrane protein that is expressed on a variety of tumors, including melanoma, breast cancer, malignant gliomas and leukemia (53–55). This evidence concerns the gene CSPG4 and malignant glioma.