CD4 and enterovirus infectious disease: In the analyses of the highly activated Treg cells (CD4+CD127−/loCD25+FOXP3high Tregs), the FOXP3 expression level was decreased in the infants who had enterovirus infection during the preceding 30 or 60 days period [p = 0.008 and p < 0.001 (p = 0.04 and p < 0.005 after correction for multiple comparisons); Figure 3D].