However, certain isoforms have been described in specific disease settings such as IL-36α in arthritis (Frey et al., 2013) and IL-36γ in psoriasis (D’Erme et al., 2015), with the blocking of IL-36γ achieving a reduction in psoriasis-associated inflammation in a 3D skin model (Todorovic et al., 2019). Here, IL36G is linked to arthritic joint disease.