Li et al. found that treatment with mesenchymal stem cell-derived exosomes decreases the atherosclerotic plaque size in ApoE−/− mice, inhibits the expression in macrophages of increased M2 markers and lipopolysaccharide-induced M1 markers, promotes M2 macrophage polarization through the miR-let7/HMGA2/NF-κB pathway, and suppresses macrophage infiltration via the miR-let7/IGF2BP1/PTEN pathway in plaques, which attenuates the progression of atherosclerosis (16). The gene discussed is NFKB1; the disease is atherosclerosis.