Drug interactions: Acyclovir, angiotensin converting enzyme inhibitors, digoxin, diuretics, non-hormonal anti-inflammatory drugs, tricyclic antidepressants, beta blockers, chloroquine/hydroxychloroquine, ritonavir, lopinavir, streptomycin, phenytoin, levodopa, antipsychotics, tapazole, tenofovir, tetracycline, warfarin  Diseases: Renal diseases, seizures, hypothyroidism, cardiac disease, diarrhea, sodium depletion, fever, neutropenia, dehydration. This evidence concerns the gene ACE and kidney disorder.