Drug interactions: Amiodarone, antidepressants, betablockers, ciclosporin, cimetidine, clarithromycin, digoxin, fluconazole, glibenclamide, insulin, linezolid, aspirin, lorazepam, ibuprofen, lamotrigine, gabapentin, omeprazole, opioids, oral anticoagulants, ritonavir, triptans, tryptophan, warfarin, verapamil  Diseases: Hyponatremia, seizures, QT prolongation, SIADH, liver disease, platelet function, renal disease, glaucoma, diabetes. This evidence concerns the gene INS and kidney disorder.