Drug interactions: Adrenalin and sympathomimetic amines, anesthetics, antihistamine, antidepressants, caffeine, carbamazepine, cyproheptadine, clonidine, clozapine, decongestants, disulfiram, ginseng, insulin, levodopa, lithium, methyldopa, opioids, nitrates, oxcarbazepine, tyramine, triptans, tryptophan  Diseases: Heart disease, cerebrovascular disease, use of sympathomimetics, thyrotoxicosis, pheochromocytoma, liver disease, renal disease. This evidence concerns the gene INS and hereditary pheochromocytoma-paraganglioma.