Because the NLRP3 inflammasome is activated in human mesenchymal stem cells via lipopolysaccharide and palmitic acid, and plasma (Fu et al., 2019) levels are increased in the context of obesity (Wang et al., 2017), Hcy might be one of the mediators involved in obesity-induced insulin resistance. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.