The protection against acute AA-induced tubular cell damage and renal function impairment is consistent with other studies in which JNK inhibition suppressed acute kidney injury induced by renal ischemia/reperfusion injury (IRI) or cisplatin (Francescato et al., 2007; Wang et al., 2007; Kanellis et al., 2010). Here, MAPK8 is linked to acute kidney injury.