The 20 core targets were closely related to cancer pathway (hsa05200), TNF signaling pathway (hsa04668), MAPK signaling pathway (hsa04010) and P13K-AKT signaling pathway (hsa04151), and are related to diseases such as hepatitis B, colorectal cancer, non-small cell LC and small cell LC (Figure 9B). Here, TNF is linked to hepatitis B virus infection.