TP53 and non-small cell lung carcinoma: Related studies showed that the MAPK signaling pathway participates in the regulation of cell cycle, apoptosis and proliferation of NSCLC cells, and inhibits the expression of P-glycoprotein (P-gp), multidrug resistance gene 1 (MDR1), TP53 and other proteins, thus inhibiting the growth of NSCLC cells, blocking cell cycle and inducing apoptosis (Liao et al., 2020; Qiao et al., 2020; Wang et al., 2020).