Expression levels of SMAD2/3 and Collagen1A were associated with the airway hyperresponsiveness in asthma, and the JTE-013 administration significantly decreased the airway hyperresponsiveness-related proteins in asthma, indicating that the S1P2 receptor is involved in both inflammation and airway remodeling processes in asthma. Here, SMAD2 is linked to airway hyperresponsiveness.