AKT1 and Alzheimer disease: Alterations in the phosphatidylinositol 3-kinase and protein kinase B/Akt PI3K-AKT pathway in both T2D and AD patients have been observed by numerous studies suggesting this pathway may play a critical role in the development of AD among T2D patients (Liu et al., 2011; Gabbouj et al., 2019; Santiago et al., 2019).