CNR1 and juvenile absence epilepsy: In the WAG/Rij strain, a model of absence seizures with a subpopulation also susceptible to AS, systemic administration of WIN 55,212-2 reduced the number of spontaneous spike-wave discharges, but increased seizure duration, in WAG/Rijs, whereas administration of AM251 attenuated the effects of CB1R activation (Van Rijn et al., 2010).