Recent RNAseq analysis of HD patients’ motor cortex revealed that mutant huntingtin interferes with RNA processing and induces aberrant alternative splicing (Table 1), affecting the expression levels of TRANS-splicing factors and/or trapping specific RNA binding proteins (Sathasivam et al., 2013; Lin et al., 2016; Schilling et al., 2019). Here, HTT is linked to Huntington disease.