DYRK1A is affected in 21q22 microdeletion in human, and is associated with growth retardation, primary microcephaly, facial dysmorphism, seizures, ataxic gait, absent speech and intellectual disability (Møller et al., 2008; Courcet et al., 2012; Ji et al., 2015; van Bon et al., 2016). The gene discussed is DYRK1A; the disease is Intellectual disability.