This may apply to most amyloidogenic proteins, including cystatin C and the stefins A and B, which are involved in the typical amyloid disease; the hereditary amyloid angiopathy (cystatin C) or in a progressive myoclonal epileptic syndrome EPM1 with features of neurodegeneration (stefin B) and are non-physiological (such as stefin A) serving as model proteins in our previous work on protein aggregation to amyloid fibrils (stefins A and B) (Žerovnik et al., 1999, 2010; Anderluh and Žerovnik, 2012). The gene discussed is CST3; the disease is amyloidosis.