BDNF and Anxiety: For example, WD-associated anxiety-like behavior is accompanied by increased expression of 5HT-r1a and GABAa alpha2 receptor subunit in the ventral HPC (Bannerman et al., 2004), as well as elevated brain-derived neurotrophic factor (BDNF) expression in the dorsal HPC (Peleg-Raibstein et al., 2012), a region where BDNF levels correlate with the magnitude of anxiety-like behavior in the EPM task in wildtype mice (Yee et al., 2007).