Considering the widespread distribution of mGluR5 (e.g., CNS, liver, hepatocytes, thymus, immune cells), further studies are necessary to address the mechanisms behind VU0490106 anti-inflammatory properties in obesity (Boldyrev et al., 2005; Ferrigno et al., 2017). The gene discussed is GRM5; the disease is obesity due to melanocortin 4 receptor deficiency.