APOE and Alzheimer disease: Impaired memory-relevant behavior with APOE4 has been reported both in the presence and absence of Aβ in vivo (Thomas et al., 2016, 2017; Zaldua et al., 2020), and data are conflicting on whether ARB treatment considerably modulates memory-relevant behavior in AD-relevant mouse models (Wang et al., 2007; Mogi et al., 2008; Takeda et al., 2009; Tsukuda et al., 2009; Danielyan et al., 2010; Ferrington et al., 2011, 2012; Ongali et al., 2014, 2016; Torika et al., 2016, 2017, 2018; Royea et al., 2017; Trigiani et al., 2018).