E4FAD− and E4FAD+ mice were selected for this study as they express human APOE4 and exhibit age-related changes in memory-relevant behavior and functions described as potential targets of ARBs (AD-relevant pathology: neuroinflammation, Aβ levels, and cerebrovascular dysfunction; Youmans et al., 2012; Tai et al., 2017). This evidence concerns the gene APOE and Alzheimer disease.