Considering that QBP1 was recently found to bind and exert anti-aggregation property not only to polyQ proteins but also to glutamine-rich regions of the pathogenic amyloidogenic proteins such as TDP-43 (Mompeán et al., 2019), an aggregation-prone protein involved in the pathomechanisms of amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD), further studies are strongly awaited to increase the bioavailability of QBP1 itself or its derivatives or analogs. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.