Non-allele specific ASOs for SCA7 (Niu et al., 2018), HD (Kordasiewicz et al., 2012; Stanek et al., 2013), and SBMA (Lieberman et al., 2014; Sahashi et al., 2015), and allele-specific ASOs for HD (Sun et al., 2014; Rué et al., 2016; Datson et al., 2017; Southwell et al., 2018) that are effective in the mice or non-human-primate model of each disease have also been identified. The gene discussed is ATXN7; the disease is Huntington disease.