Considering the potential involvement of the RAS in the pathophysiology of BD and its potential therapeutic implications, we carried out a cross-sectional study analyzing the levels of RAS-related molecules- ACE, angiotensin-converting enzyme 2 (ACE2), angiotensin-II (Ang II), and angiotensin (1–7) [Ang-(1–7)]- among patients with BD compared to healthy controls (HC). The gene discussed is ACE; the disease is Behcet disease.