In the same way, by activating Sirtuin-1 (SIRT1)-related pathways, the probiotic treatment of transgenic AD mice led to conserved brain function (Bonfili et al., 2017), a protein deacetylase that, through activating SOD2 and catalase, reduces the reactive oxygen species (ROS) levels in the brain (Cheng et al., 2014). This evidence concerns the gene SIRT1 and Alzheimer disease.