The mRNA expressions of TJ proteins (ZO-1, occludin, and claudin-1) in mice decreased significantly in the stroke 1-day group (n = 5, p < 0.001, Figure 4(b)), but the difference had not reached significance after 7 days of stroke (n = 5, p > 0.05; Figure 4(b)). The gene discussed is CLDN1; the disease is stroke disorder.