The final effector of the TLR4 signaling pathway, NF-κB, which plays a crucial role in the translation and transcription of inflammatory mediators, promotes the development of inflammatory bowel disease (IBD), and the TLR4/NF-κB signaling pathway may be critical to the intestinal barrier function and mucosal inflammation [28, 29]. The gene discussed is NFKB1; the disease is inflammatory bowel disease.