The most common driver mutation in MPN occurs in exon 14 of the Janus kinase 2 (JAK2) gene, JAK2V617F, causing constitutive JAK-signal transducer and activator of transcription (JAK-STAT) signaling and driving the aberrant proliferation that is characteristic of MPN. This evidence concerns the gene SOAT1 and myeloproliferative neoplasm.