There were significant negative correlations between circulatory efficiency and LV myocardial mass (r = − 0.591, p < 0.001), myocardial fibrosis volume (r = − 0.427, p = 0.015), end systolic volume (r = − 0.609, p < 0.001) and NT-proBNP (r = − 0.444, p = 0.009) and significant positive correlation between circulatory efficiency and LV ejection fraction (r = 0.704, p < 0.001). This evidence concerns the gene NPPB and Myocardial fibrosis.